Sarcopenia is one of the musculoskeletal consequences of hypovitaminosis D. Geriatric giants, such as sarcopenia (progressive and generalized loss of skeletal muscle mass and strength) or cognitive decline, strongly influence elderly patients.
This is a typical example of the situation where a lack of “hard evidence” is not synonymous with the possible lack of adverse effects. The phenomenon of drugs and vitamin D interactions is observed first and foremost in patients with comorbidity. The known factors affecting vitamin D metabolism interfere with cytochrome CYP3A4 activity. Therefore, all factors interfering with individual metabolic stages may affect 25-hydroxyvitamin D plasma concentration. Vitamin D status in geriatric population is an effect of joint interaction of all vitamin D metabolic pathways, aging processes and multimorbidity. In this group, low vitamin D plasma concentration is related to osteoporosis, osteomalacia, sarcopenia and myalgia. Vitamin D deficiency is common in elderly people, especially in patients with comorbidity and polypharmcy.
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